The use of peptides by bodybuilders is still relatively new… so in an attempt to find out more about their applications and benefits I interviewed one of the premier research scientists at a lab responsible for their production.

In the weeks ahead I will examine many of these substances, but I thought I would start off with one of the most popular products on the market, the peptide known as Long R3 IGF-1 …

For those not familiar with this compound can you tell us a little about it?

“IGF-1 is basically a polypeptid hormone that has the same some of the same molecular properties as insulin. In fact, IGF actually stands for insulin-like growth factor. IGF-1 is primarily responsible for long bone growth in children and it also affects muscle growth and repair of adults. Long R3 IGF-1 is a more potent version of IGF-1. It’s chemically altered to prevent deactivation by IGF-1 binding proteins in the bloodstream. This results in a longer half-life of 20-30 hours instead of 20 min.

What benefits can it offer the bodybuilder?

IGF-1 greatly boosts muscle mass by inducing a state of muscle hyperplasia (increase in number of new muscle cells) in the body,.

How does its effects compare to that of Growth Hormone?

“Long R3 IGF-1 can directly stimulate muscle growth when compared to growth hormone (GH). This is because GH indirectly results in growth and repair by first inducing IGF-1 release in the liver.If you don’t have to worry about IGF-1 release in the liver (because your directly injecting the IGF-1), new growth will be optimized.”

Is there a benefit to using both of these substances together?

“Many research studies have shown that GH and IGF-1 act synergistically to augment the effect of either hormone taken individually. So, the greatest results will take place when effective dosages of both hormones are injected. Usually 10-20mcg of IGF-1 (post workout) and 2-4IU GH (with breakfast) is the ideal stack for optimal reults and minimal side effects.

Certain steroids such as NPP and Trenbolone (to name just two) actually increase IGF-1 production. Could someone still benefit from adding it if they were using one of these substances?

“The IGF-1 that’s produced from the use of fast acting Nandrolone or Trenbolone is nothing signficant when you compare to the amount that’s contained in a single 10mcg Long R3 injection. Having said that, it’s safe to inject exogenous IGF-1 while taking either one of these compounds.

Is IGF-1 of greater or lesser value when it comes to healing injured tissue?

“Tissue build up is one of the main features of IGF-1, so I’d say it’s of greater value. IGF-1 can genetically change muscular and cellular counts within the body; it can also enhance the body’s ability to regenerate damaged tissue. In fact, IGF-1 is now under intensive research for its potential to repair tissue in burn patients, and for its regenerative effects on AIDS patients suffering from muscular wasting. Immediate effects are, of course, impossible to observe since it takes a respectable amount of time to see any visible changes in muscular repair.”

Due to its effects on insulin should diabetics exercise caution when using it?

“Not really; aside from the fact that “more is not better”, there’s no known lethal risk of administering IGF-1 to diabetic patients. In fact, IGF-1 can reduce the body’s need for insulin, and according to one short study, it can reduce insulin dependence of the body by as high as 45%. This may bring very promising results if we are allowed to study this matter further. If anyone experiences any uncomfortable side effects, stop it’s usage and see if the side effect disappear.”

What is the difference between LONG R-3 IGF-1 and the standard IGF-1?

“Just as it was mentioned earlier, Long R3 IGF-1 is a chemically altered version of IGF-1. It has added amino acid chains that prevent it from being deactivated by IGF-1 binding proteins in the bloodstream. This gives Long R3 IGF-1 a much longer half-life. It’s the 83 amino acid equivalent of IGF-1 that consists of the complete human IGF-1 sequence substituting the Glu (E) to the Arg(R) at position three. The structure also has an added 13 amino acid extension peptide by the N terminus. Overall it’s a more biologically active version of the original IGF-1.”

How is IGF-1 best mixed and stored?

“Assuming that we use the lyophilized form (dry powder) of Long R3 IGF-1, equivalent to a 1000 mcg vial, it is best prepared by using 1ml or 2ml of acetic acid. Let the acetic acid seep into the vile after removing the vacuum from the container. Then, let the mixture in the vial sit for a while. Put it in the fridge where the IGF-1 mixture can dissolve without accidentally knocking the vial or shaking its contents. Then afterwards, it’s all about diluting your Long R3 IGF-1 in NaCl or bacteriostatic water before intra-muscular or subcutaneous entry.”

What is the best way to use it in your opinion?

“The best way to use it is to use it in regulated dosages. Ususal dosages of Long R3 IGF-1 are 10mcg to around 50mcg per day. IGF is usually available by the milligram (1000mcg), which is equivalent to using 20mcg a day for 50 days. But for the most part, the actual dosage depends upon how much the person is able to spend on Long R3 IGF-1, although most are usually satisfied with the 20mcg per day dosage. Additionally, IGF is also best taken either IM or subcutaneously, having more direct effects on the body when injected. It’s also recommended to be taken during the morning or after weight training sessions.”

Is there a benefit to using it bi-laterally in trained muscles after workouts?

“Well, if one feels like getting both sides to grow equally for a shorter time, then I guess yes, there are certain benefits. There are some bodybuilders who practice this method because they feel like one part of their muscle group grows faster than others. And some just like the idea of being able to develop multiple muscle groups simultaneously. The truth is that once injected, the IGF-1 enters the bloodstream and doesn’t stay, locally, in the particular muscle it was injected into. By that token, IGF-1 might as well be injected into a single injection site.”

What is the best dosage and length of cycle?

“The regular dosage of most users of Long R3 IGF-1 is 20mcg a day. The 20mcg value is acquired from the total amount that you have to take within 50 days. It’s usually already effective at this rate, as it is enough to be fully absorbed by the body to achieve the desired effect. Most users and even bodybuilders alike are also satisfied with the said dosage, although they may take the dosage at different times during the day than others. Too much IGF-1 will result in downregulation of IGF-1 receptors on the surface of muscle cells. This will essentially hault any gains from the injected IGF-1 since very little receptors means very little response!”

Are effects more immediate than with GH use?

“Yes, based on the facts mentioned earlier, effects are more immediate. IGF-1 is the compound that directly reacts with the proteins in the body, and consequently also directly effects muscle and tissue growth. GH on the other hand, is only the one who signals the other compounds to react (IGF-1 being one of those compounds), making the process quite slower. Therefore, effects are definitely quicker and faster when you use IGF-1 instead of ordinary GH.”

Finally, are any side effects attached to its use?

“IGF-1 is commonly known to cause feelings of fatigue. Some people feel very tired quickly when using this compound. It can, however, be looked at in a more positive light since more sleep means better growth. Other side effects include muscular stiffness, headaches, occasional nausea, and some also claim that it’s sometimes responsible for hypoglycemia or low blood sugar.”

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On occasion, elite bodybuilders stay on steroids for several years at a time. This is due to the fact that they must be in shape for multiple contests as well as guest appearances throughout the year. This non-stop regimen has claimed some victims. Mendenhall comes to mind. This guy had the potential to be one of the best bodybuilders in history. Yet, he admittedly burned out on steroids before he could even claim a national championship. Hill is another bodybuilder which I have recently seen suffer from the demanding, non-stop steroid regimen required at this level. After rocketing to the top, he has recently dropped out of sight. Demelo was another up and coming national competitor who burned out on steroids and never made it. I think he is trying to make a “natural” comeback – - good luck, bud. Santoriello took a serious setback after his teenage success before coming back to win the national championships. I heard that he was messed up by steroids. Some don’t think he can make it as a professional because of the amount of drugs he has to take to stay in shape. (Oh, I mean the amount of Cybergenic Kits – give me a break!). Numerous pro bodybuilders and active top level national competitors find themselves in similar situations. Their contest schedule is just too busy for off cycle periods. Since their success is so heavily dependent on being in top shape, steroids become an absolute must for their program all year long”.

Athletes have many reasons for coming off of anabolic steroids, but the most common reason is because of the health risk involved with continuous use of the substance. Coming off of steroids can have varying affects which often make the athlete nervous because there is no guarantee how the body will react to the absence of the substance once it’s used to getting the supplement. Some common symptoms of stopping steroid use include the following:

• weight loss
• muscle loss
• lowered body strength
• increased body fat
• depression and lethargy
• fear of lowered performance levels

One of the reasons why is the body stops producing testosterone at its normal levels during steroid use and the body has a difficult time adjusting to the lack of testosterone. This is what makes steroid use so “addicting”. Sometimes it seems easier to go back to steroid use than to deal with the side effects. If athletes take the right precautions, however, getting off of steroids with the least possible side effects and the least possible performance loss is possible. Here are some things for any athlete to keep in mind:

• Coming off of anabolic steroids takes planning. It’s not best to just decide to go “cold turkey” because the body can enter a catabolic phase which includes a decrease in strength and mass and lack of desire to train.
• Steroids should be reduced slowly for two to four weeks depending on the strength of steroids the athlete is taking.
• Additionally, athletes to make sure they also control the production levels of other types of hormones in the body as well. This can be done by having the athlete take a strict regimen of other drugs including antiestrogen drugs, Clomid and HCG.
• When coming off of a steroid regimen the athlete should also alter his or her nutrition. Calories should be decreased by about one-quarter to one-third over several days without altering protein intake much.
• Exercising regimens should also be decreased as well because the body won’t be prepared to maintain the same level of training while coming off of the steroids. For information on post cycle products, visit the Muscle Labs USA website.

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You’ll find nothing like exiting the gym, taking a shower and not having the ability to bathe because your wasted from your training session. Your thighs and legs are shaky, together with your arms can’t move. But maybe you have trained too hard, have you done more damage than good.

Weight training to failure in your training programs is something you hear many people discuss and every discussion finds you just as confused. Just about every individual you look over, talk with as well as meet gives you a different account. Some even go as far to say if reps and sets even matter.Die hard weight lifters depend on absolute fatigue feeling that failure is essential.

Certainly there’s two sides to every report.

For all workout partner or self proclaimed bodybuilding authority that swears working out to total fatigue is crucial, you will find an equal variety that say, stay away from that, Exercising in that method definitely will demolish all your muscle building growth. A handful declare leave one in the tank.

Some go as far as saying discontinue when the velocity associated with the weight happens to be substantially slower.

So who is right?

This article will help you determine if working out to failure is a good idea and will add more mass even more then in the past or maybe if it probably will wipe out your perseverance in the gym.

Both statements have a degree of truth to them. Each training method has its time and place. That doesn’t answer your question. Kind of leaves you were you started this search.

For most of your exercises, and the majority of your sets, you will not train to failure.

When to End Your Set

There are essentially 3 circumstances that will actually influence the exact ending of your respective set:
the rate in which you move the dumbbell is without question noticeably reduced
once you think that you merely possess 1 more rep that you can get
training to failure
Look At The Bar Tempo

I will briefly summarize this method only for the reason that as a body builder or perhaps someone aiming to add muscle mass this most often just isn’t a technique that you employ.

Never ever train to failure any time you are focusing on speed, power, or explosiveness. Bar speed is essential if training for power in addition to explosion, certainly not too much of a matter throughout the body building realm along with those aiming to develop bigger physique. For anybody who is an Olympic lifter, power lifter, or part of a strength and power sports activity you are going to certainly employ this technique, this process is a essential part of their workouts.

You’ll see an Olympic lifter as well as a power lifter miss a lift. This will likely happen a variety of specific motives however be certain never to confuse it as being training to failure. When this occurs they’re usually close to a one rep max, not ever performing repetitions until they fail. And they only approach this weight on occasion.

Have One More Rep In You

The next level in the In the previous example you are usually a few reps from leaving it all on the table.

When it come to the compound exercises like deadlifts, shoulder press, pull ups, and the likes… it’s not a good idea to rep out.

Preferably you’ll force it to the stage you know you will get the lift without a little extra help from a friend. You already know you will get that final rep. Your final rep can be hard but in no way should you need any help. Do not attempt the rep if there is any question at all about being able to do it without a spotter..

This is actually most appropriate training methodology intended for building muscle mass and adding more lean muscle. Working out in like this is much easier on your central nervous system, something people often forget about when it comes to their recovery.

Some people have pushed ever set and every rep to the max, maybe that is you, but that can’t last long. Short-term success is possible. If you are lucky you make even build some muscle mass and get stronger. But your time will pass. Consistently train to failure and it will not take long for your body to break down. When this happens, all you have worked for starts to take a backward slide. Your mass gains will halt, you may even start to lose weight. Your strength will decrease, and you may end up weaker than before.

In case it is something you insist on doing, only do so every now and then. Maybe once a month on your very last set you can actually push the limits and train to full muscle failure, but constrain it to that.

Training to Failure, When is it OK

In cases where you might be a bodybuilder and you are attempting to pack on some significant muscle mass this strategy is without a doubt accepted and low risk with the smaller sized muscle groups. This is often the place you experience drop sets and supersets creep into play. However, this is not appropriate for each and every set of every accessory exercise.

A perfect instance of this is with your biceps exercises. Sometimes bodybuilders will do as many reps as they can with a specific weight then drop some weight then continue to do more repetitions until they can’t, drop a little more weight and continue. This get repeated either for a set number of reps or until all the weight is gone. Doing this you will reach true muscle failure.

Your biceps will definitely be small in comparison to the lower body musculature thus this particular technique is not near as stressful on you or even your nervous system as say a squat drop set would definitely be. In this case it is actually alright to train to failure because it’s relatively safe and can be successfully done without a lot risk of injuries.

This may be something you could do fairly frequent yet limited to the final set of your accessory exercises.

Naturally with every thing comes a given component of danger therefore make certain to pay attention to your body and whenever it doesn’t feel right stop short of failure.

Overall recommendations to follow

For no reason train to failure on an explosive movement Only train to failure once in a while or using minor muscles just like biceps and triceps Any time your body tells you to stop… quit!

I hope I have cleared matters up for you when it comes to training to failure. As we discussed training to failure is not as cut and dry as you may have primary imagined. But if you implement these basic polices and suggestions when making your weight training program you’ll end up on the track for good results in addition to significant lean muscle gains.

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